The Cargo holds below the floor ARE Pressurized. The reality of the physics is that the fuselage of the plane is airtight and nearly round, so it is able to withstand the pressure easily. The Floor is flat and if it were sealed and pressurized it would have to be heavily braced to prevent it from buckling. And, all those cargo planes without floors and seats would have to be manufactured differently from the passenger planes…. A big headache for the manufacturers. Again … The Cargo holds below the floor ARE Pressurized ... Even in the little puddle jumpers.
That said, the planes are not pressurized back to sea level pressure. The cabin is typically pressurized to the equivalent of 8000 feet. Except for the people that do heavy exercise during the flight, most folks are very comfortable at that equivalent altitude.
To make the math easy, let’s call Sea Level =15psi, 8000ft = 11psi, and 35,000ft = 3 psi. In flight you and your gear are stressed by 4psi (15-11) difference from the ground. And the hull of the plane takes the other 8psi (11-3). To pressurize the plane all the way back to sea level , it would have to withstand the full 12Psi (15-3) and need to be 50% stronger (12psi/8psi).
But all this is moot. Your first stage regulator is trying its best to get the second stage hose up to 150 psi so you can breathe. The first stage valves are wide open when the valve is off the tank, and this is the reason you do not want to rinse your regulators without air pressure on them. This means the pressure on both sides of the second stage regulator are the same and there is NO pressure difference. The last item to consider is the first stage “Dust Cap”. There could feasibly still be the 4psi difference if the cap is truly air tight. So if you want to be really “Monk-ish”, loosen the Dust Cap before packing it.
In consideration of Lost Luggage. Unless the Bag falls off the plane in flight, it is almost never “Lost”. Go visit the lost baggage area at an airport and you will see that they know WHERE all the bags are. They just don’t know WHO they belong to. The Bags aren’t lost, the owners are! The one thing they all have in common, is the tags are missing. Consider your own bags, if the tags were missing, could someone still tell they belonged to you? The airlines do not want your stuff! They will open any lost bags to try to identify the owner. Make it easy for them. Place a copy of your itinerary and contact information INSIDE of your bags and they will never be lost. The Tags will be lost, the Handles may be gone, but the bag will still find its way home. I have had luggage that was “lost” and did not even have to go to the airport to get it. The airline had it delivered to our destination, 35 miles from the airport. Remember the secret is to --- Place a copy of your itinerary and contact information “INSIDE” of your bags!