So you're saying it would still be accurate deco information even if you were to switch it off after the dive has started?
The deco information is always accurate based on the gas you are breathing. If you have selected an incorrect gas, your deco information would be incorrect. That's true of any computer, it only knows what you tell it.
The only issue having a different PO2 set for bottom and deco mixes is the point at which it will alarm, and the depth at which it will alarm, based on the PO2 you tell it you want it to alarm at. If you tell it your bottom mix wants to be 1.4, and you blow your MOD and the PO2 is 1.5, it will yell at you. If you have your deco gases set at 1.6, it will simply allow you to breathe your deco gases with a higher PO2 before telling you that you're doing something wrong.
You could put 100 gases in and have them all active and it will still provide the correct decompression obligation as long as you have the actual gas you are breathing selected. The TTS may not be correct, and the "stop time" will not decrease at the actual rate, but that's the only place it's making assumptions. It will tell you there's a better gas, and if you use a "bottom" gas at a PO2 higher than what you have set in the settings, it will alarm, but it will not change anything that actually has an effect on your dive, your decompression obligation, or your safety.