Many divers have said that they feel better after nitrox. I have no idea but suspect that it might be somewhat of a placebo effect.
Two questions. First, is there any possibility that the phenomenon of divers reporting that they "feel better" even though there is no measurable decrease in DCS can be explained as Nitrox decreasing sub-clinical DCS symptoms?
I used Nitrox most of last year, and the few times I didn't use it, I definitely felt fatigued and had the sniffles. Then I was doing some reading and the subject of bubbles provoking an immune system response came up, and this seemed to explain my (anecdotal!) experience: I may have been feeling my immune system's response when diving air rather than any direct DCS symptoms.
This possibility also addresses the question of why some people report feeling no benefit when diving Nitrox. If we are not talking about actual DCS but rather we are talking about the body's immune system responding to bubbles in the blood stream, some people may be more sensitive to bubbles than others. In which case the answer might be, "if you are sensitive to bubbles, then Nitrox is important for you." is this conjecture reasonable?
Second, Nitrox does reduce the EAD, thus you get longer bottom times. True. But there's another factor I have not seen discussed outside of some technical manuals. When the dive is complete and you decompress, if you are diving Nitrox you have a slightly better gas gradient since the N2 partial pressure in your breathing gas is lower than air.
This is obviously a very big deal for divers using 50%, 80%, or 100% O2 as a decompression gas. But wouldn't breathing 32% or 36% Nitrox provide a small benefit to assist off-gassing more efficiently? To be specific, I am wondering whether the following is true: Given two identical divers, one on air and one on Nitrox, if both dive to their NDL at the same depth, I would expect their tissues to have the same amount of nitrogen at the completion of their bottom time. Now both ascend using the same protocol. I now expect the Nitrox diver to have less nitrogen in her tissues than the air diver because the gas gradient assisted off-gassing during the ascent.
I am probably over-thinking Nitrox here, but I have been wondering about this recently...