one-off gas selections may make sizable changes to my deco, I may feel differently.
I don't know what you define as "sizable" but if you stick to some basics like rock bottom <100cf, ENDs 100ft or less, deco ppO2s of 1.6 stuff like this its actually pretty hard to generate wildly different results by tweaking the gases.
Ie.
EAN80 is not that much different than O2
EANxx is not that much different than EAN50
21/35 and air are for most practical purposes interchangable...
Saving 3mins here vs there is within my fudge factor, although I suspect many of the posters here would consider 3mins at some point in the dive significantly "different".
Cut with an axe and all that jazz.