Unless you are diving a shell drysuit with minimal undergarments you will lose buoyancy from a full flood, you will not be neutral.
Even if you dive with a squeeze on, your body mass, the various creases in the suit and the thickness of the garment full of airspace, all create displacement. That displacement equals your buoyancy (plus whatever your rig is doing).
When you flood, water fills the air space in the creases and your clothing, and that is the amount of buoyancy you will lose.
For some people this could be a little or a lot. Look at what you wear and how much air it traps. I know people who wear two sets of wool socks, fleece and a puffy vest. Add up the volume of all that air space, plus the volume of bubble they usually run in the suit and express it as water weight. That's how heavy one will be when fully flooded.
Here's an experiment:
Take all your undergarments;tops, bottoms and socks, and put them into a bucket. Push down (that's diving with a squeeze on) and mark the bucket as to how full it is.
Now weigh that bucket of garments on a scale (not much eh).
Take out the garments and fill the bucket with water to the fill line.
Weigh the water on the scale (more eh).
Subtract the weight of the garments from the weight of the water and what you are left with: That's how heavy you will become (plus the volume of creases in the suit, boot space, and the bubble you weight yourself to ordinarily run with that will also fill with water).
As someone who solo dives in cold, remote settings I think about this a lot. Besides a medical event (stroke, heart attack etc...), a full flood would probably be the worst thing that could happen to me when you consider shock, hypothermia and exhaustion. Shore diving would be problematic enough but from a boat it would be very difficult to manage. Having an exit strategy is an important part of my pre-dive planning.