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Doxycycline use to reduce death in DCS cases

Discussion in 'Diving Medicine' started by loosenit2, Oct 14, 2019.

  1. loosenit2

    loosenit2 Solo Diver

    i thought this was some interesting initial research. The US Naval Medical Research Center is exploring the use of Doxycycline in conjunction with recompression treatment. The initial trials were with swine, but indicated that the administration of doxycycline in cases where there was a delay in getting to a recompression chamber reduced death rate.

    The first link below has one slide that summarizes the study thus far (along with a whole lot of other presentations)

    https://www.navsea.navy.mil/Portals...ad Booklet 2019.pdf?ver=2019-05-09-121100-303

    NMRC Researchers think a Common Antibiotic can Save the Lives of Divers Suffering from Decompression Sickness
  2. Esprise Me

    Esprise Me Kelp forest dweller ScubaBoard Supporter

    # of Dives: 50 - 99
    Location: Los Angeles, CA
    Can anyone translate that into layman's terms?
  3. drjtprice

    drjtprice Nassau Grouper

    # of Dives: 100 - 199
    Location: Saxlingham Nethergate England
    Might be more reason to use doxycycline as an antimalarial in areas where it still works for that purpose. Just in case it has other side benefits to reducing malaria risk...
    Frogkicker and Seaweed Doc like this.
  4. uncfnp

    uncfnp Solo Diver

    # of Dives: 500 - 999
    Location: North Carolina
    I admit my statistical analysis courses were many years ago but this seems odd...

    “Johnson and his colleagues, conclude doxycycline reduces mortality, although this effect was not statistical significant.”

    Conclude doxy reduces mortality but not statistically significant. So how the heck did they make that conclusion?
    Storker, FreeFlyFreak and Esprise Me like this.
  5. drjtprice

    drjtprice Nassau Grouper

    # of Dives: 100 - 199
    Location: Saxlingham Nethergate England
    Usually it means it did not meet the standard of p<.05 (in some fields, like the hunt for Higg's Boson, the p value desired was even higher). Basically, the odds of achieving the result by chance alone being less than 5 in 100. Without knowing the sample size (to assess statistical power), the test performed, and the p value it is hard to assess.
    Seaweed Doc likes this.
  6. Seaweed Doc

    Seaweed Doc Marine Scientist

    # of Dives: 500 - 999
    Location: Seattle, Washington State, USA
    I think (not an MD) that it basically means it stops your body from destroying itself in response to the "insult" of a bubble.
    Esprise Me likes this.
  7. runsongas

    runsongas Great White

    # of Dives: 500 - 999
    Location: California - Bay Area
    seems like there are multiple studies on whether ketogenic diets prevent CNS o2 toxicity.

    one on developing a portable, collapsible chamber.

    and one on Viagra to prevent IPE. i'm sure that one isn't awkward.
  8. drjtprice

    drjtprice Nassau Grouper

    # of Dives: 100 - 199
    Location: Saxlingham Nethergate England
    At risk of taking the thread even more off topic there was research showing Viagra could reduce jet lag...in hamsters
    chillyinCanada and Esprise Me like this.
  9. Sh0rtBus

    Sh0rtBus BUBBLLLLLLES! My Bubbles ScubaBoard Supporter

    # of Dives: 100 - 199
    Location: Denton, TX
    Okay great now it's possible an antibiotic can reduce DCS mortality rate when getting to a chamber is delayed. Wouldn't it be a better option to perform in-water recompression at that point?
  10. happy-diver

    happy-diver Skindiver Just feelin it ScubaBoard Sponsor

    # of Dives: 100 - 199
    Location: same ocean as you
    Just remember that not much of any treatment is going to save anyone
    when you've messed up real bad and all your heart has to pump is froth

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