Piscean
Registered
Hello Paul,
So, I think we agree. Thanks for filling in the bit about the CO2 buffering, I didn't know why execise increases the susceptibility to Ox Tox, but it sounds like that could be one of the reasons. Do you know where I could look up the pH dependence of the haemoglobin dissociation curve?
You are right of course about the oxygen in the tissues:
So what else? I think we get back to your earlier mathematical gymnastics if we start on the MOD diluent question. Maybe I'll do that later, but I'm at work at the moment so maybe I should concentrate on that, but basically, I agree with you.
In the meantime shall look forward to your next poser.
Ciao,
Piscean.
So, I think we agree. Thanks for filling in the bit about the CO2 buffering, I didn't know why execise increases the susceptibility to Ox Tox, but it sounds like that could be one of the reasons. Do you know where I could look up the pH dependence of the haemoglobin dissociation curve?
You are right of course about the oxygen in the tissues:
I meant to say in the blood in the capillaries in the tissues but I just got lazy and inaccurate in my writing.You say " If we breathe ppO2 at 3 bar then I suggest the ppO2 in our tissues will be 3-2.6 = 0.4 bar. (The 2.6 difference comes from the 6 ml of O2 that gets metabolised.) " I am not sure this is strictly true. While this may reflect what is seen in the blood, all tissues have a lower oxygen tension than seen in venous blood. In addition there are the confounding variables of differing tissue metabolic rates, variable blood supplies to those tissues and in addition the auto-regulation of blood supply to the brain. (CNS oxygen toxicity is not seen outside the brain!)
So what else? I think we get back to your earlier mathematical gymnastics if we start on the MOD diluent question. Maybe I'll do that later, but I'm at work at the moment so maybe I should concentrate on that, but basically, I agree with you.
In the meantime shall look forward to your next poser.
Ciao,
Piscean.