boulderjohn:I have never heard this before. Do you have a reference for this?
Found it myself. Here is an article from DAN:
http://www.diversalertnetwork.org/medical/articles/article.asp?articleid=51
The evidence is not really good--mostly anecdotal, and not many anecdotes. On the other hand, there is some indication that drugs like Sudafed may excite the central nervous system and potentially increase the potential for CNS toxicity.
The conclusion is to avoid it if you are diving EAN to the point that your PO2 level might exceed 1.4a. Note that this is the normal safe limit for EAN, so it should be OK if you are not exceeding that limit.
Here is the key paragraph:
What's the bottom line? In normal, healthy divers breathing air, occasional use of pseudoephedrine at the recommended dose is probably safe. This presumes that the drug has been taken during periods when no diving has occurred and that no undesirable reactions have occurred. However, one should avoid chronic (daily) use when diving, and it seems reasonable to avoid the drug entirely if diving while using oxygen-nitrogen mixes where the PO2 during a dive might exceed 1.4 ata, the current recommended "safe" open-circuit scuba limit.