The 1.4 / 1.6 is already a built in safety margin.
As to feeling better after nitrox... Sub-clinical DCS, that feeling of fatigue after a dive, I have read, can be due to the body acting on the increased nitrogen in the blood / tissues in a way that is similar to it fighting off the flu. Thus flu like fatigue, which is lessened by less N2 in the body.
I also feel better after doing deco on 100% verses 50% or 80%.
If this is all hogwash, please don't tell me and spoil the nice placebo effect I have working for me.
Check out the rebreather forums and discussions on modifying PPO2 levels based on depth and length of dive - There are good examples of individuals suffering oxygen toxicity between PPO2 1.4 and 1.6. The initial symptoms present themselves as involuntary spasms in their arms and legs and the individuals have recognized what was happening and moved to a shallower depth/lowered their PPO2 levels. I'm not aware of basic Nitrox training that recommends diving beyond 1.4 and certainly not beyond 1.6 PPO2.