Just don't do what a DM did at the Flower Gardens a couple of years back.
Floating on the surface near the boat, he apparently decided to try the "chaw" he (for whatever reasons) had brought on the dive with him.
A wave surprised him and he aspirated the tobacco. He was found on the bottom several hours later, but it took some time to figure out what happened.
(As for the CO tolerance of physically fit "smokers" being higher, that might be true and might be a reason that some smokers can' more easily fight the urge to breathe on C02 buid-up, but I would certainly like to see more than anecdotal assessents. Certainly, the damage caused by smoking mitigates much of this inferred advantage. Sounds like a DAN paper to me.)
I did not smoke until my late 20's, when I took up the habit while working on offshore oil rigs. I was a 2-packer at my peak, but managed to get off the habit by my early 30's, so I only smoked a few years. That was over ten years ago and I haven't smoked since.
My air consumption was always very good, even exceptional, whether I was smoking or not. Over the last few years, despite the fact that I am stronger and more aerobically fit than I used to be, my air consumption crept up to the point it was embarrassing for me. I was a "reggler" diver again.
On my last trip, though. I was very relaxed, very happy to be underwater. I ended up first in, last out, on almost every dive, usually with 1000psi or more in my tank. I didn't calculate consumption, but it was very very good.
For that reason, I think experience, experience, experience are 3 primary factors in air consumption, with fitness and body mass coming next in line.....