Since it was assumed, reverse profiles have not been, and never will be, large scale tested, so everyone is sort of guessing about how reverse profiles might change things. Isolated research results on non-humans can only provide guidance, but since military and commercial have no need to do repetitive dives, and dive computers have made tables (or at least human subject research) obsolete, a firm answer about reverse profiles might never really be known.
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If dive computer manufacturers were required to sell computer interfaces with dive computers, then we might get some large scale results. As it is now though, the people most likely to do repetitive reverse profiles are tropical guides, who also do a bunch of other things (rapid ascents, multiple dives over multiple days) that increase risk. So when we get bent, and we do get bent, who can say which of the risk factors contributed most?