Using altitude procedures and decompression modelling software I can track and plan for the difference in pressures in my body tissues. An airliner cabin is pressurized to a minimum of 11psi, or the equivalent of 8000 feet. Using my flight times and altitude tables I can create a simulated deco profile within MultiDeco of my flight. I make sure that I don't cross a gf line of 80/80 before I fly, taking into account the rapid off gassing during ascent to cruising altitude.
DAN guidelines are conservative to the point that no one would have to worry about any of this, their dcs risk is near-as-makes-no-difference zero. That's why I called them super conservative though I can see why you would debate that description.
I don't recommend a diver flaunt flight guidelines without thorough understanding and planning. The existing guidelines are extremely safe, but like all incidences of increased conservatism it comes at the cost of decreased efficiency. If one is willing to do the research and planning they will find they can travel safely much soober than Dan guidelines in most cases.