Few studies have evaluated the relative efficacy of DEET and picaridin in fending off ticks, black flies, sand flies, no-see-ums, midges, and other biting insects. Available evidence indicates that picaridin and DEET are both effective at repelling black flies, while DEET is more effective at preventing tick bites. Conversely, picaridin seems to be better at repelling other biting insects, notably no-see-ums. The insect composition of your travel destinationand perhaps some personal field testswill determine which repellent works best for your needs.