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How will it self inflate if it's not hooked up to anything? There will be an atmospheric drop in the hold that may allow some expansion but in a tightly packed bag the BC should not be affected. If you're really worried unscrew one of the dump valves.
---------- Post added November 18th, 2014 at 09:44 PM ----------
Less ambient pressure means any air put in at sea level in a closed flexible container will expand as the ambient pressure drops. Unless the plane crashes and drops to the bottom of the ocean. Then it will get smaller.