scubaren
Contributor
There was a Smithsonian workshop reported in 2000 on the subject of reverse profiles. The proceedings are available through the Rubicon Research Repository (link to abstract is HERE). They concluded that there was no evidence to indicate significantly increased risk from diving reverse profiles as long as the dives were shallow and the depth differences were less than 40 feet.
There was a recent paper involving guinea pigs that showed more significant problems, but there were methodological issues with the study.
Most models will give you definitely shorter no-deco times if you dive reverse profiles.
How do they get those cute little Guinea Pigs in scuba gear? I'd love to see that!