the 300/600 mentality is really cave specific because it allows you to dive thirds as victor said. I tend to breathe right tank down a third, then left tank to third, turn, and stay on the left tank most of the way out. When I hit 2/3's on that I'll switch back to the right for the rest of the ride. That works for tanks in the HP100 range because it's a little less than 3lb weight difference at switch which is manageable.
The PST tanks exhibit more stable buoyancy swings, so depending on how large your tanks are, and if they get butt floaty depends on when I switch.
I do 600psi on my left, 1200psi on my right, then 1200psi on my left in my HP120's, that's about a 1.5lb offset in buoyancy for 600psi difference. In OW I tend to a bit more liberal and will typically do it in 1000psi increments depending on my mood. Down to 2500psi on right, down to 2000 psi on left, then switch a bit more frequently after that, but it takes a long bloody time in OW to breathe down that far.
Like everything for me in diving, adapt to the conditions at hand.